I'm using Norton Power Eraser and it pick up this flie for me to eraser:
Is it safe to remove C:\WINDOWS\system32Drivers\upcleanhlp.sys
Is it safe to remove this? I'm not sure.
That's a legitimate file name that comes as part of Microsoft's User Profile Hive Cleanup Service. If you've installed that software, then leave it alone. If you're not familiar with it then that file might be risky.
If I send you instructions via private message, would you be willing to upload a copy of that file? I'd like to see if it's legitimate (in which case we'll make sure never to detect it again), or if it's a threat you should remove.