Backup Strategy for Dual Internal Hard Drives wG15?

I have a new notebook computer running Windows 7 HP (64-bit) that has an internal 640GB (320GB x 2) dual hard drive.  The data stored is as follows:

OS(C): 205GB free of 282GB
DATA (D): 297GB free of 298GB
RECOVERY (E): 2.46 gb free of 14.9GB

 

I also have an external 250GB hard drive.

 

I have read the software documentation and searched online on precisely how to back up the drives.  I had to use Ghost once in the past to reimage a hard drive and I want to make sure I am doing it correctly.  Can someone provide some guidance in plain English as to how I should optimally do this?  You assistance will be appreciated.

 

Keith