Browser Hijacked by Istart123 and Safhomepage.com

My browsers has been hijacked by Istart123 and/or safhomepage.com and I can not get rid of it.   Have tried Norton erase.  Running on windows 7 explore 11.  Have removed Chrome and foxfire.  run Malware program and have had not success stopping the browsers.   Help  SPEDGOal