Can't save settings changes

I recently upgraded to the NIS 2012 version and cannot get any of my changes to the settings to change. I cannot set up a full scan scedule that runs at the correct time, I cannot apply/save the changes to performance monitoring, nothing that I change in the settings can be applied/saved. When I change something the apply button lights up but does nothing when I click it, and when I click ok to get out and come back in it to settings it is back to what it was before I changed it.  What can I do to solve. I tried uninstalling and reinstalling and nothing.  Please help.

Thanks