Connection to mail server interrupted

I'm setting up my Backup software to send me email messages when it completes or fails. When I click on the test button I get a dialog stating that it has been sent (see attached Image1.png). However, soon after that I get a Norton dialog stating that it failed because the connection to my mail server was interrupted (see attached Image2.png).

What do I need to change in NIS to make this work?

[Admin Edit: Removed attachments with personal email address]