Desk Tray Icon follow up

Someone posted a thread in October about their desk tray icon having a white 'X' on it.  I'm having a similar issue.  Mine has the red circle and exclamation point that won't go away even after I've run a virus scan.  Is this just a hang-up or an indicator of something more?  I went to the Norton site and had a scan run there too.  Restart?  Thanks for any info!