.exe file isn't allowed to run

I have several programs that I download that come as an .exe executable file. They are programming programs for my ham radios. I know they are safe but they update every so often. They go to my download file but Norton will not let them run.

What do I need to temporarily turn off to run them?

in Norton 360 you have Settings /scans and risks  there u have the posibility to exclude files folders and other things from scans