How to Exclude output of specific Apps from NIS Virus Inspection?

How does one Exclude the Files output by specific Apps from NIS Virus Inspection ??

I have several Trusted Apps which produce Numerous Large Files as part of their normal Operation.  I know that they are NOT Virus-infected, and I don't want NIS to consume CPU and Disk I/O - especially while I'm working in those Apps.

An example are my Compiler Runs - I know and trust the content.

Another example are my Astrophotography Images - where content is trusted and multi-GB of Image Data are read and written as intermediate products that need no Scanning.

I don't necessarily want to Exclude Folders, as that means I cannot share those Folders with other Apps and other Data Sources without Compromising Security.  I want to Exclude Apps - more specifically Exclude the Files that they Access.

Suggestions ??