NIS 2011 Full Reputation Scan Freezes brings net framework error

Version 18.5.0.125 when I try and run a full reputation scan it freezes again and brings an internal framework error. One Click support states error 8504,104 or something about net framework error 3.5 is there such a thing. Is there anything I can do with Microsoft update that could prevent this, it wanted to report the error to Microsoft, I rebooted and it NIS 2011 seems to be working again........Thanks for any help........Gorpy1