Norton Ghost 14 backup destination will be wiped????

I have a 320 gig external drive with nearly 240 gigs of music, movies, photos, programs and such.  When I went to do an entire backup I get the message that "destination drive will lose all stored data" (something to that effect).  Is there some way to prevent this from happening?  I want to copy my entire C drive, but don't want to lose all my stuff.  Help, please!  Thanks.