Norton Security and iPod Shuffle sync issues

Computer #1: OS - Win XP, SP3, 2GB RAM, current license and version of Norton Security.  I have used the current versions of NS and an older version of iTunes, version 10.7, together for years with no problems.  In December 2014, I updated iTunes to version 12.0.1.26.  Almost immediately thereafter, although my iPod Shuffle 2nd Gen continued to be properly detected by iTunes 12, I was unable to sync the iPod Shuffle with iTunes ("unknown error occurred (-53); disk is not available").  I recently upgraded to iTunes version 12.1, with no change to my problem or to the error messages.

After many hours with Apple Support, all to no avail, the only solution that allowed my iPod to work perfectly with iTunes was to uninstall NS.  Now that I have re-installed NS, the same problems persist - cannot sync iPod Shuffle with iTunes.

Computer #2: OS - Win 7, 8 GB RAM, current license and version of Norton Security.  As a test, I installed iTunes old version 10.7 from Apple website.  Again, iPod Shuffle 2nd Gen was properly detected by iTunes but was not able to sync.  Again, the only solution was to ininstall NS.  After re-installing NS, the same problems persist.

Apple Support told me to ask Norton Support for a solution.  I would appreciate your assistance in learning how to make NS and iTunes co-exist with one another.