The only piece of SystemWorks 2009 (12.0) that I still use (due to a lack of any good alternative) is Norton System Doctor. Initially it wouldn't start at all on Windows 10, reporting a problem with the mechanism it uses to identify the OS version. Using compatibility settings set to XP or Vista didn't help.
After tinkering with other versions of SystemWorks I discovered that I could rename SYMMIGR8.dll (to anything) and it works great. Given the amount of things it can monitor, I can only vouch for Disk Space, and Disk I/O via Performance Data - which are the only two things I like to have persistent on my desktop.
Unlike Win 7, you do need to run it in Compatibility mode as Vista SP2 in order for some of the UI to be rendered and handle correctly. I'd stay clear of any other parts of SystemWorks that do anything other than "monitor" things, since alternatives for most of those features have made it into current versions of Norton Utilities.