Hi GordoB:
If the MBAM scan doesn't detect any serious threats, one of the best malware removal experts in the forum, Quads, often recommends that users install the portable SUPERAntiSpyware scanner (available for download here) on a USB drive and try a remote scan.
Norton has a utility called Norton Power Eraser (available here) that is an extremely aggressive scanner and targets threats like rootkits that may go undetected by traditional anti-virus scans, but NPE often detects false positives and can remove important system files if used incorrectly (see delphinium's comments here in the Norton Protection Blog). It should be safe to run this tool in diagnostic mode (see RichD's instructions here) but I wouldn't allow this tool to "fix" any files unless you can confirm that you are infected with a virus that cannot be removed by any other method. I may revise my opinion of this tool once Symantec has completed the beta testing of NPE v. 2.x (see here for more info) but in the mean time I would use the NPE with extreme caution..
I'm not a malware removal expert, but if you're receiving bogus e-mails and all your scans with NIS, MBAM and SUPERAntiSpyware are clean then it's always possible that the people in your address book are the ones who are actually infected. You may just be one of the unfortunate souls receiving spam e-mail from their computers, and you should be able to set up a rule in your e-mail program to have these incoming e-mails moved immediately to your trash folder so that you don't accidently click on the link in these e-mails and infect your own compter. In my Windows Mail program I can do this at Message | Create Rule From Message.
It's also possible that your poor system performance has nothing to do with these e-mails, so if you can't find any malware on your system you may find some of the troubleshooting tips here in Patrick McCabe's thread Is Norton Slowing Down My Computer? helpful in diagnosing the problem. The Idle Time Optimizer (a disk defragger that comes with NIS) and Norton Community Watch are two resource-intensive NIS tasks mentioned in that post that can be disabled without decreasing your system protection.
If your can't find any malware on your system, post back with some information about your Windows OS, whether you recently installed or upgraded NIS, and your current NIS version (go to Support | About - the latest NIS 2012 is currently v. 19.2.0.10). It would also be helpful to have some information about your system hardware (e.g., amount of RAM, CPU speed - go to Start | All Programs | Accessories | System Tools | System Information), the speed of your Internet connection, and your default web browser (e.g., IE, Firefox, Chrome, etc.). You can check to see if your PC meets the minimum system requirements for running NIS here - just click on the System Requirements tab.
Edit:
And please let us know if you've ever had other security software from another manufacturer (e.g., McAfee, AVG, etc) running in real-time protectiion mode on your PC. Residual registry entries and files from old security programs can sometimes conflict with NIS and other Norton software and slow your system down - see lowries4 thread here titled Help! Computer Running Very Slow and Affecting Internet Speeds for one example.
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Windows Vista Home Premium 32-bit SP2 * NIS 2011 v. 18.6.0.29 * IE 9.0 * Firefox 9.0.1
HP Pavilion dv6835ca, Intel Core2Duo CPU T5550 @ 1.83 GHz, 3.0 GB RAM, NVIDIA GeForce 8400M GS