"Core Product . . ." Problem

Recently I have been getting the following error message: "Core Product files(s) have been modified.  Please run Smart Update or reinstall the product".  Smart update says I am up to date and ignoring the message doesn't seem to do any harm (?).  It is annoying though.  A search of past messages revealed that this problem was detected and fixed at least a year ago with version 16.0.1.7  and I am running version  21.6.0.32

Two questions: Is this a real problem that I should be concerned about  and how to I get rid of the messages.

 

Thanks