Settings change when click apply

I was wandering if anyone can help me I had a problem with a winrar download managed to sort that through following process on here, ran superspyware and hijackthis and deleted the correct entries in the systemfiles. But was unsure of one of the symantec so didn't delete it because it didn't match exact.

 

But after this I noticed when going into the internet security general options I cannot click the box how to protect your PC from unauthorized changes, so I clicked apply page defaults and it ticks the box when click apply it changes back to UN ticked.

 

I have also noticed I can never get my ActiveX to work in the internet options tried numerous things and really struggling any ideas would be much appreciated.