System Restore point error -2147212542 when running Registry Cleanup?

Since the 19 September, whenever I run Registry Cleanup, the above error message occurs and the Registry Cleanup will not run, due to the fact that it cannot find a System Restore Point.  I have tried to run System Restore but it will not operate.  I received help from Norton Support via remote operation of my computer but they could not solve the problem, at the time and said they would contact me again within 3 days, in order to fix it.  Nobody came back to me to solve the problem.  Help!  

Since the 19 September, whenever I run Registry Cleanup, the above error message occurs and the Registry Cleanup will not run, due to the fact that it cannot find a System Restore Point.  I have tried to run System Restore but it will not operate.  I received help from Norton Support via remote operation of my computer but they could not solve the problem, at the time and said they would contact me again within 3 days, in order to fix it.  Nobody came back to me to solve the problem.  Help!