The operating system is not presently configured to run this application

The message "The operating system is not presently configured to run this application" appears for all Microsoft Office apps after installing Norton Security Deluxe- 5 Devices.  Installed due to expiring license for Norton Security with Backup (For 10 Devices).  I found a work around, disable Exploit Prevention (Settings/Firewall/Intrusion and Browser Protection).  I'd rather see this fixed without disabling what maybe important protection.

Is there a permanent fix?  What exposure is there when Exploit Protection is disabled?