Allow the file onto computer and to be run

Exactly how configure N360 versions 21 and 22 to allow a file to be both downloaded and later, to be run?  I can open the N360 setting but not know what to do to make those settings.  One of the computer help websites provides several security scanning and cleaning tools, and attempt to download and then to run one of their files was interrupted as Norton 360 stopped it and removed it, saying in the notification several things including  WS.Reputation.1.