Cloning a drive to Upgrade

Can Ghost 15.0 clone a working laptop drive with 512 byte sectors to a new 750G Seagate drive with 4K sector size?  The original drive is functional but full and I have a USB carrier connect the new drive to the same machine to do the clone.   Do I need to make an intermediate backup and then restore or can I do it in one step to make the new drive bootable as the replacement.