I get a popup almost every few hours stating "Action Required...Threat Detected"

Hi, I have several questions:

I get a popup almost every few hours stating "Action Required...Threat Detected".  I've done research and don't understand the ramifications of what these mean.  I have 2 SecurityRisk.gen1 and 1 PUA.Gen.2.
Do I need to remove these? 
Are these really threats that I need to worry about???

I don't see an "IGNORE" button, but the darn "Threats Detected" splash screen keeps popping up over and over.  Why?

If I do remove them (not even knowing why), is it possible I might lose some other application functionality that I may need in the future?
Can they be "restored" and un-quarantined?

Thank you

[Edit: Calrified the subject]