I want to eliminate SSD from Optimize

Hello, I need to subtract my SSD from the Optimize function. I want Optimize to work with my main C drive, regular HD, only.

I have a Train Sim installed on the SSD and every time it optimizes, certain portions of the SIM get erased. Just a note, to say that ot os ONLY after running the optimizer this happens.

I just want to stop Optimizer from running on this SSD, not my HD.