Norton NIS and imaging programs

I'm thinking of reinstalling my NIS 2011 but first I'd like to know about how it behaves with Macrium refect. My main cocern is if I'm making an image and all of a sudden Norton stars running the background house keeping what effect does it have on my image that is in progress? If it has any effect I guess I can always use my Win PE disk to make the image. How does it get along with MalwareBytes and ThreatFire?