PCAnywhere File Transfer Problem-Connection to Host Machine Lost

I use PCAnywhere to mirror a hard drive. I have 2 hard drives in the same computer. On a weekly basis, I use "File Transfer" on PCAnywhere to back up a data file folder on one drive to the other drive. 

 

This is worked fine over the last few years. Lately, when it is half way through the process, I get a message "Connection Lost Do you want to save a command queue?

 

What is causing this? I am suing PCAnywhere 12.1 on a Vista computer with a Quad Core processor.

 

It has worked flawlessly in the past.