Upgrade SAV to SEP question

I'm upgrading from SAV 10.0 to SEP 11.0.5.  Built a new management server, etc.  I noticed on a test deployment that the Client machine needs a reboot, but it does look as if the Anti-virus client is running.  This is used on our servers, 600+ of them.  Obviously we can't reboot them at anytime we want.

 

I'm wondering if I push out to them, a hundred or so at once, are we still protected if they don't get rebooted right away?

 

Thanks,

George