Virus keeps re-appearing with system restore disabled

Hey there, I keep having trouble with a virus on my computer. I run a scan, my Norton finds and remvoes a "Trojan.Maliframe!html", but next time I run a scan, say, after a restart start, it turn sup with another of those viruses. Typically I would suspect that system restore was restoring the virus, however I double checked and my system restore is completely disabled. Can anyone tell me what's causing my problem and how I should go about fixing it? Thank you!