I purchased Norton Security Premium (2017) about a month ago. I've installed it on four Windows 10 computers. Three have been fine. However, on one computer I immediately experienced periodic freezing of the entire system. Typically it was about 2-4 hours after system startup. I would be working in an application, and suddenly on clicking on a button or menu item, the window would display the busy cursor and show "non-responsive" in the title bar. Upon clicking in any other window, or on the Taskbar or Start Menu, they too would become non-responsive, so that the entire system would not respond to clicks or keyboard. I would have to do a cold shutdown with the power button and restart.
After several days of this, and suspecting the issue was Norton, I uninstalled it and reinstalled my previous antivirus software (whose license was timing out in a few days). I ran with that previous software for a couple of days, with no further freezes. Then I tried uninstalling the previous antivirus and reinstalled Norton Security. Once again I began experiencing the freezing issue.
I contacted Norton/Symantec via their Support system, and got on the phone with a support person. He wanted to do a remote-control session, which I agreed to. He ran through a few standard updates and cleanup--nothing that I could see would help, but pronounced things fine. After signing off, I continued to experience the freezing issue.
I contacted Norton again, this time using the chat option. Again the tech did a remote control session, and proceeded to delete Windows Temp files and a few other seemingly unrelated things, and then started to turn off several of my startup programs. I stopped him because I could see it would not help. He then suggested the problem must lie with Windows and wanted me to contact Microsoft. After a good guffaw about that, I reminded him that the problem has only appeared on this computer with Norton installed. He then went off for a while (presumably to confer with coworkers), and then came back and disabled the Performance Monitoring aspect of Norton Security. He rebooted the system and then pronounced the system healthy. I reminded him that the problem never occurs until at least an hour after system startup.
He basically gave up at that point. I continued to experience the freezing issue. I tried disabling various parts of Norton, such as the firewall and other processes. None of that helped--freezing continued. I finally disabled the antivirus protection, and that seemed to help. So I concluded that at least on this system, Norton is simply incompatible with some aspect of the system. Getting Norton to track it down seemed futile, so at that point I just purchased a one-system license for a competitor product. It's been several days with no further freezes.
This was on an older Windows 10 Pro i7 system from circa 2011. The problem appeared when running a variety of programs, including different browsers, Microsoft Visual Studio, Microsoft Office/Outlook, and so on, but I could see no pattern in terms of software conflicts. I suspect there was some background process/driver that conflicted, but I don't have time to try to track it down further.